Human perforin gene variation is geographically distributed

Human perforin gene variation is geographically distributed

BACKGROUND Deleterious mutations in PRF1 result in lethal, childhood disease, familial hemophagocytic lymphohistiocytosis type 2 (FHL 2). However, not all mutations in PRF1 are deleterious and result in FHL 2. Currently, these nondeleterious mutations are being investigated in the onset of numerous disorders, such as lymphomas and diabetes. Yet, there is still an overwhelmingly large amount of ...

Managing Geographically Distributed Teams

This paper summarizes recent literature on virtual organizations, as well as Tec-Ed’s practical experience in managing project teams whose members are in different geographic locations, have different skills and responsibilities, and seldom meet face to face. It reviews how we share corporate culture, gain insight into clients, build trust, and develop the professional synergy that enables effi...

Geographically Distributed Software Development

Geographically distributed software development holds much promise for increasing market penetration and speeding up development cycles. However, it also comes with a set of new challenges for those developing the software, bought about by the distance among colleagues. This paper outlines a new research project underway to explore those issues and their implications for organizing g eographica...

Perception of geographically conditioned linguistic variation

Fast Hybrid Simulation with Geographically Distributed Substructures

A distributed control strategy is presented that supports the implementation of hybrid (pseudodynamic) testing with geographically distributed substructures. The objectives of the distributed controller are: (1) to provide a scalable framework for multiple substructure testing at distributed sites and (2) to improve the reliability of the test results by minimizing strain-rate and force relaxat...